بروتين الدماغي الاولي المدر للصوديوم ,مصل

The significance of natriuretic peptides in the control of cardiovascular system function has been demonstrated. Studies reveal that natriuretic peptides can be used for diagnostic clinical problems associated with left ventricular dysfunction.4 The following natriuretic peptides have been described: atrial natriuretic peptide (ANP), B-type natriuretic peptide (BNP), and C-type natriuretic peptide (CNP).5,6 ANP and BNP, as antagonists of the renin‑angiotensin‑aldosterone system,influence by means of their natriuretic and diuretic properties, the electrolyte and fluid balance in an organism.7,8 In subjects with left ventricular dysfunction, serum and plasma concentrations of BNP increase, as do the concentrations of the biologically inactive prohormone, proBNP.
ProBNP, comprising 108 amino acids, is secreted mainly by the ventricle and, in this process, is cleaved into physiologically active

BNP is a highly sensitive and specific marker for left ventricular dysfunction and is used to follow up ventricular function in response to medical management. BNP determinations have shown the potential to be a good prognostic marker for morbidity and mortality in patients with heart failure, including predicting future cardiac events in patients with acute exacerbation. BNP appears to have clinical utility in excluding a diagnosis of heart failure in patients with symptoms of breathlessness or fluid retention.

1 ml Serum Stability: 3 Days: 20‑25 °C 6 days 2‑8 °C 24 months at ‑20 °C Freeze only once.

Avoid haemolysed samples.

Acute HF likely: > 900 pg/mL Acute HF less likely: 300 - 900 pg/mL Acute HF unlikely: < 300 pg/mL