17-Hydroxy Pregnenolone, Serum

The steroid 17-OH-Pregnenolone is the immediate precursor of 17-OH- progesterone and DHEA through the enzymatic action of 3-β-OH-steroid dehydrogenase and 17, 20- lyase respectively. 17-OH-Pregnenolone is formed from Pregnenolone, the first derivative of cholesterol in steroidogenesis, through the action of 17-α-hydroxylase.

17-Hydroxy Pregnenolone levels are elevated in patients with idiopathic hirsutism. 17-OH-Pregnenolone levels remain in the normal range in patients with Cushing’s disease. 17-Hydroxy Pregnenolone levels can be suppressed with Dexamethasone inhibition and increased with exogenous ACTH stimulation. Levels during the follicular phase tend to be higher than during the luteal phase.

2 ml Serum Room Temperature

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