الوصف
5-HIAA is the major product of the oxidative de-amination of serotonin, a derivative of the amino acid tryptophan. Serotonin is a potent muscle stimulant and vasoconstrictor that is formed in the enterochromaffin c cells of the gastrointestinal tract. Thus, 5-HIAA levels reflect serotonin synthesis. See Also 5-Hydroxytryptophan , and Serotonin
دواعي الإستعمال
5-HIAA levels are increased in metastatic carcinoid tumours. High 5-HIAA levels are associated with midgut carcinoids, while slight elevations are associated with non-tropical sprue. Decreased levels are found in phenylketonuria, renal insufficiency, depression and small intestine resection.
نوع العينة والكمية والشروط
30 ml of 24 Hrs urine
إحتياطات خاصة
State 24 Hrs urine volume. Adjust pH to (3-6) with Hydrochloric Acid.
المعدل الطبيعي
< 15.0 mg/24 Hrs < 78.45 nmol/ 24Hrs