Carbamazepine (Tegretol), Serum/Plasma


Carbamazepine is a drug commonly indicated as first-line therapy for simple partial, complex partial, and general tonic-clonic seizures. Carbamazepine is also approved by the US Food and Drug Administration for trigeminal neuralgia, bipolar disorder, neuropathic pain, and attention deficit/hyperactivity disorder. Among anti-epileptic drugs involved in toxic ingestion, carbamazepine is the second most common, after valproic acid. Acute carbamazepine toxicity presents with cardiac (hypertension, hypotension, tachycardia, and cardiac conduction delays), respiratory depression, and neurologic (loss of consciousness, seizures, ataxia, choreoathetosis, myoclonus, motor restlessness, opisthotonus, mydriasis, and nystagmus) effects.

دواعي الإستعمال

Measurement of carbamazepine level is performed to ensure concentrations within therapeutic range and avoid drug toxicity.

نوع العينة والكمية والشروط

1 ml Serum 1 ml K2-EDTA or Li, Na-Heparin Stability: 24 Hours at Room Temperature 7 Days at 2-8 °C > 7 Days at -20 °C

إحتياطات خاصة

Time to reach peak serum concentration is 4-8 Hrs after dose administration. Avoid haemolysed samples. Avoid more than 3 freeze/thaw cycles.

المعدل الطبيعي

Therapeutic Range: 4.0-12.0 µg/mL Toxic Level: > 12.0 µg/mL

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