Trisomy 18 (Edward’s syndrome), Fluorescent In Situ Hybridisation


Trisomy 18 (Edward’s syndrome) is the second most common autosomal trisomy in newborns. The condition is usually the result of malsegregation (non-disjunction) of chromosome 18 in meiosis in either oogenesis or spermatogenesis. In Several studies, the parental origin of the extra chromosome 18 was found to be maternal in about 91% of the cases. The prevalence of females with trisomy 18 in liveborns indicates a prenatal selection against trisomy 18 males.

دواعي الإستعمال

Trisomy 18 by FISH is used to confirm the diagnosis of Edward’s’ syndrome in suspected individuals. This test is also used as a prenatal diagnostic tool, (when performed on amniotic fluid), to confirm or rule out Edward’s’ syndrome pregnancies, especially after triple or quadruple test results suggestive of high-risk pregnancy. This test offers an advantage over traditional chromosomal Karyotyping as it is rapid, results are usually reported within 24 hours, allowing for enough time to consider the future of a given pregnancy.

نوع العينة والكمية والشروط

7 ml Heparin Whole Blood/Amniotic Fluid Room Temperature

إحتياطات خاصة

المعدل الطبيعي

By Report

Scan the code
Hello 👋
هل يمكننا مساعدتك؟