X,Y Chromosomes, FluorescentIn Situ Hybridisation


In mammals, the male-specific Y chromosome plays a pivotal role in sex determination. Like other mammals, human females have two X chromosomes (XX) and males have a single X and a single Y chromosome (XY). The X chromosome is large (5% of the total length of a single set of chromosomes) and bears a proportional number of genes (3000 or 4000), which have a variety of functions much like those of genes located on other chromosomes. In female cells, only one X chromosome is genetically active. The Y chromosome is much smaller than the X chromosome and contains only a few genes and is largely composed of repetitive sequences.

دواعي الإستعمال

X/Y chromosome determination is useful in the sex assignment of a newborn with ambiguous genitalia (Congenital Adrenal Hyperplasia), the diagnosis of X/Y related syndromes such as the XXY Klinefelter syndrome, the XO Turner syndrome, Triple X (super female) syndrome and sex mosaicism. X/Y chromosomes determination is also useful in PGD( Pre-implantation Genetic Diagnosis) in cases of X-linked heritable genetic diseases.

نوع العينة والكمية والشروط

3 ml Heparin Whole Blood / Amniotic Fluid Room Temperature

إحتياطات خاصة

المعدل الطبيعي

By Report

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