17-Hydroxy Pregnenolone, Serum


The steroid 17-OH-Pregnenolone is the immediate precursor of 17-OH- progesterone and DHEA through the enzymatic action of 3-β-OH-steroid dehydrogenase and 17, 20- lyase respectively. 17-OH-Pregnenolone is formed from Pregnenolone, the first derivative of cholesterol in steroidogenesis, through the action of 17-α-hydroxylase.


17-Hydroxy Pregnenolone levels are elevated in patients with idiopathic hirsutism. 17-OH-Pregnenolone levels remain in the normal range in patients with Cushing’s disease. 17-Hydroxy Pregnenolone levels can be suppressed with Dexamethasone inhibition and increased with exogenous ACTH stimulation. Levels during the follicular phase tend to be higher than during the luteal phase.

Sample Type, Quantity & Conditions

2 ml Serum Room Temperature

Special Precautions

Normal Range

By Report

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