Description
Eosinophils (white blood cells), are bone marrow-derived granulocytes with a richness of surface receptors for immunologic ligands. Eosinophils characteristically harbour specific granules which, besides some 20 known chemokines, cytokines, and growth factors, contain large amounts of the tissue-toxic cationic proteins major basic protein, eosinophil cationic protein, eosinophil peroxidase, and eosinophil-derived neurotoxin. Eosinophils have many roles ranging from immuno-regulation to tissue remodelling and repair and the killing of foreign organisms.
Indications
Despite their role in immuno-regulation and in fighting parasites, eosinophils are implicated in several disorders. Eosinophilia is strongly associated with allergic reactions and asthma. Eosinophils are increased several days before kidney and liver graft rejection. Moreover, eosinophilia can be associated with several cancers. However, they are considered to be a good prognostic factor and correlate with longer years of life.
Sample Type, Quantity & Conditions
1 ml EDTA Whole Blood Room Temperature
Special Precautions
Normal Range
Adults: Up to 450 cu.mm Up to 0.45x10^9/L Neonates: Up to 800 cu.mm Up to 0.80x10^9/L
