Alpha-2- Antiplasmin, Plasma

The plasma proteinase inhibitor, α-2-antiplasmin, is a strong inhibitor of plasmin, the ultimate enzyme of the fibrinolytic system. α-2-antiplasmin with the help of the cofactor XIIIa binds fibrin thus,
reducing its breakdown. α-2-Antiplasmin levels correlate with antithrombin III and plasminogen levels, suggesting that the synthesis of these proteins in the liver is closely linked.

Severe α-2-antiplasmin deficiency due to homozygous mutations leads to unrestrained fibrinolysis and severe hemorrhagic diathesis. Heterozygous mutations lead to mild hemorrhagic diathesis. α-2- antiplasmin, anti-thrombin III and plasminogen are used in the diagnosis and follow up of parenchymatous liver disease. In cholestatic jaundice, however, none of these blood coagulation tests have prognostic significance.

1ml Citrate Plasma Frozen

% of Pooled Normal Plasma: 80 - 120