Ammonia, Plasma


Ammonia is produced by de-amination of amino acids in the liver as well as by urea-splitting bacteria in the gut from where it is absorbed. Ammonia is a toxic substance that is rapidly metabolised to urea by liver enzymes and excreted in the urine.


Increased plasma ammonia levels are seen in fulminant hepatic failure, cirrhosis, gastrointestinal bleeding, portal-systemic shunting of blood, renal disease, genitourinary tract infection and Reye's syndrome.Increased plasma ammonia levels are also seen in several inborn errors of metabolism such as hyperammonemia types I and II, argininamia, ornithinemia, citrullinemia, lysine intolerance, hyperlysinuria, and dibasic aminoaciduria type II.

Sample Type, Quantity & Conditions

2 ml EDTA Plasma Keep under ice

Special Precautions

Tube must be filled completely and kept tightly sealed at all times. It is preferable to use a vacutainer. Mix well. Place on ice immediately. Separate plasma within 15 minutes of venipuncture.

Normal Range

By Report

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