Angiotensin Converting Enzyme (ACE), Serum/Plasma


The primary function of ACE is to help regulate arterial pressure by converting angiotensin I to angiotensin II. Angiotensin II causes narrowing of the small blood vessels in tissues, resulting in an increase in blood pressure. It also stimulates aldosterone secretion, which causes an increase in blood pressure.


This test is used primarily to detect and monitor the clinical course of sarcoidosis and to delineate between active and inactive sarcoid disease. Elevated ACE levels are found in a number of other conditions including diabetes, hyperthyroidism, Gaucher's disease (a rare familial disorder of fat metabolism), and leprosy.

Sample Type, Quantity & Conditions

1 ml Serum 1 ml Heparinized Plasma Stability: 1 Week at 2-8 °C Several Months at -20 °C

Special Precautions

Discontinue administration of captopril, enalapril, or lisinopril for 12 Hrs prior to venipuncture, as these reduce ACE activity.

Normal Range

Adult: 20-70 U/L Children: 29-112 U/L Sarcoidosis: 45-135 U/L

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