Apolipoprotein A1, Serum

Apolipoprotein A1 (Apo A1), the major protein component of highdensity lipoprotein (HDL), is essential for the formation of HDL particles. In addition, Apo A1 may play a direct role in atherogenesis by acting directly in the arterial wall to prevent oxidation or aggregation of lowdensity lipoprotein (LDL) or by promoting mobilisation of cholesterol from the artery wall.

This test is useful in the assessment of coronary heart disease risk. Apolipoproteins may be more specific indicators of coronary heart disease (CHD) risk than are lipoprotein cholesterol concentrations. Apo A1 measurement may better reflect disorders in the balance between HDL particle synthesis and catabolism. Low levels of Apo A-I are associated with low levels of HDL and impaired clearance of excess cholesterol from the body. Low levels of Apo A-I, along with high concentrations of Apo B, are associated with an increased risk of cardiovascular disease.

1 ml Serum 2 - 8°C or frozen

Patient must be fasting 12-14 Hrs. Separate serum and refrigerate at 2-8°C. Stable up to 3 days. Freeze if storage longer than 72 Hrs is needed.

91 - 224 mg/dL