B-Type Natriuretic Peptide (BNP), Plasma


B- type natriuretic peptide (BNP) is a cardiac neuro-hormone secreted from the ventricles in response to volume expansion and pressure overload. In general, BNP has a natriuretic and vasodilatory effect and suppresses the renin-angiotensin- aldosterone system.


BNP is a highly sensitive and specific marker for left ventricular dysfunction and is used to follow up ventricular function in response to medical management. BNP determinations have shown the potential to be a good prognostic marker for morbidity and mortality in patients with heart failure, including predicting future cardiac events in patients with acute exacerbation. BNP appears to have clinical utility in excluding a diagnosis of heart failure in patients with symptoms of breathlessness or fluid retention.

Sample Type, Quantity & Conditions

1 ml EDTA Plasma Stability: 4 Hours at Room Temperature 24 Hours at 2-8 °C 3 Months at -20 °C

Special Precautions

Avoid grossly haemolysed samples.

Normal Range

< 100 pg/mL

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