Bilirubin, Direct, Serum/Plasma


Bilirubin is more than a simple endogenous waste product that causes neurotoxicity. Uncojugated bilirubin (UCB) has a beneficial role at low, “physiological” plasma concentrations by acting as a potent antioxidant that confers hepatic, neural, and immunoprotection, by virtue of its potent free radical scavenging capacity. UCB inhibits oxidation of low-density lipoprotein (LDL) thus, reducing the risk of atherogenesis. See Also Bilirubin, Total, Serum


Elevated bilirubin levels are associated with hepatitis, neonatal and haemolytic jaundice, bilirubin encephalopathy and neural cells toxicity. Bilirubin induced toxicity will depend on UCB plasma / tissue concentrations and the extent of binding to plasma albumin, target cell / tissue involved, cellular redox state, and the patient's developmental stage.

Sample Type, Quantity & Conditions

1 ml Serum 1 ml K2, K3-EDTA or Li-Heparin Protect From Light Stability: 2 Days at 15‑25 °C 7 Days at 2‑8 °C 6 Months at (-15)-(-25) °C

Special Precautions

Avoid lipemic and haemolysed samples.

Normal Range

≤0.2 mg/dL

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