Description
Calcitonin is a single chain polypeptide hormone secreted by the thyroid parafollicular “C” cells. It is predominantly metabolised by the kidneys, however, a plasma factor contributes to some extent in its metabolism. The exact physiological role of calcitonin is not certain however, it has a modest role in lowering calcium and phosphate levels thus, inhibiting bone resorption by osteoclasts. Its secretion is modulated by rising and falling calcium levels.
Indications
Calcitonin levels are increased in patients with medullary thyroid carcinoma, leukaemia, and myeloproliferative disorders. Increased levels are also seen in hyperparathyroidism, renal failure, and chronic inflammation. In addition, lung and breast tumours may secrete calcitonin, however, calcitonin measurement is not of diagnostic value in such conditions.
Sample Type, Quantity & Conditions
1 ml Serum 1 ml Heparinized Plasma Stability: 15 Days at -20 °C > 15 Days at -70 °C
Special Precautions
Fasting sample is usually obtained to establish baseline level. Draw into ice-cooled plain tube. Separate and freeze serum immediately at -20°C in plastic tube. Avoid grossly haemolysed or grossly lipemic samples.
Normal Range
Male: < 9.52 pg/mL Female: < 6.4 pg/mL
