Cerebrospinal Fluid Index (IgG, Albumin), CSF


The cerebrospinal fluid (CSF) IgG index has been advocated as an indicator of extravascular IgG synthesis in the central nervous system. This index is calculated from the ratios of IgG concentration in CSF /serum and of albumin concentration in CSF/serum.


This index is supposed to be independent of the state of the blood - brain barrier and of changes in IgG and albumin concentrations of the blood plasma.

Sample Type, Quantity & Conditions

2 ml CSF & 1 ml Serum Preferably refrigerated.

Special Precautions

Avoid severely lipemic or haemolysed samples.

Normal Range

IgG, Serum: Age related IgG, CSF: 1.5 - 5.5 mg/dL Albumin,Serum: 3500 - 5000 mg/dL Albumin, CSF: 5.0-34.0 mg/dL Albumin Index: < 7.0 mg/dL

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