Complement Hemolytic Activity (CH50), Serum


Haemolytic assays have traditionally been used to assess the functional activity of the complement system. They provide insight into the integrity of the entire cascade reaction. These tests are particularly useful in the investigation of suspected complement deficiencies.


Detection of low or absent haemolytic activity in CH50 directs further complement analysis. Decreased activity is seen in inherited complement deficiency, mixed cryoglobulinaemia, type II membranoproliferative glomerulonephritis, immune complex disease, infectious and autoimmune processes, malignancy, trauma, burns, and liver disease. Increased activity is seen in acute phase response.

Sample Type, Quantity & Conditions

2 ml Serum

Special Precautions

Allow to clot at room temperature for 15-30 minutes. Remove serum after centrifugation, place in plastic transport tube and freeze immediately.

Normal Range

Low: 0-50% Normal : 51-150% High: >150%

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