Cyclic Citrullinated Peptide (CCP) Antibodies, Serum/Plasma


Anti Cyclic Citrullinated Peptide (CCP) antibodies (citrulline is a posttranslational modification of the amino acid arginine by the enzyme peptidylarginine deaminase) are autoantibodies found in patients with rheumatoid arthritis (RA).


Anti-CCP antibodies are efficient diagnostic markers for the diagnosis of RA with a specificity of > 95%. There is evidence that the combined testing for anti-CCP with IgM rheumatoid factor (RF) has a prognostic value; the presence of anti-CCP antibodies and IgM RF is associated with a higher probability of radiological signs of joint damage.

Sample Type, Quantity & Conditions

1 ml Serum 1 ml K3-EDTA or Li-Heparin Plasma Stability: 3 Days at 2-8 °C 1 Month at -20 °C

Special Precautions

Normal Range

Negative: < 17 U/mL Positive: ≥ 17 U/mL

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