Description
Epstein-Barr virus (EBV) is a member of the herpesvirus family and is the causative agent of infectious mononucleosis (IM) or glandular fever. EBV is transmitted by salivary contact. During acute infection, EBV primarily infects and replicates in the stratified squamous epithelium of the oropharynx. The virus infects nearly all humans by the time they reach adulthood and persists for life by balancing its ability to hide from the immune system via latent infection of B lymphocytes. There are two types of viral latency; type I and type II depending on the type of viral antigens expressed. Long term, EBV coexists with most human hosts without overt serious consequences. However, in some individuals the virus may cause malignant disease namely, Burkett’s lymphoma, non- Hodgkin’s lymphoma and nasopharyngeal carcinoma.
Indications
This test is useful in the diagnosis of EBV infections (IM). Antibody response to VCA is usually stronger than response to other viral antigens. EBV specific IgG antibodies appear within two weeks after infection and relatively high titre persist for life increasing at times of viral reactivation. If positive in the absence of VCA-specific IgM antibodies, they indicate past exposure to the virus.
Sample Type, Quantity & Conditions
1 ml Serum Stability: 14 Days at 2-8 °C
Special Precautions
Normal Range
Negative
