Description
Factor XI is a zymogen of a serine protease that participates in the blood coagulation cascade. It is synthesised in the liver and secreted into the blood as a homo-dimer. Through proteolytic cleavage, both factor XIIa and thrombin activate factor XI which ultimately activates factor IX. Deficiency in factor XI results in a bleeding disorder that is milder than hemophilia A or B. Spontaneous bleeding is rare. Abnormal bleeding usually occurs only as the result of an accident or a surgical procedure.
Indications
This test is useful in the differential diagnosis of bleeding disorders and haemophilias. Factor XI deficiency is inherited as an autosomal, incompletely recessive trait.
Sample Type, Quantity & Conditions
2 ml Citrate Plasma Frozen
Special Precautions
Normal Range
By Report
