Description
Fibrinogen is an acute phase reactant and is the principal plasma protein affecting sedimentation rate.
Indications
Useful in the diagnosis of homozygous and heterozygous fibrinogen deficiency as well as dysfibrinogenaemia; diagnosis of disseminated intravascular coagulation; fibrinogen levels can be used to assess the effectiveness of thrombolytic therapy. Fibrinogen is an acute-phase reactant and can often become significantly increased in conditions involving tissue damage, infection, or inflammation. Increased levels may be seen in smokers, during pregnancy, and in women taking oral contraceptives. Fibrinogen levels can be diminished in advanced liver disease. Very high levels of heparin or fibrin breakdown products may falsely reduce fibrinogen levels because they interfere with the rate of clot formation.
Sample Type, Quantity & Conditions
2 ml Citrate Plasma Frozen
Special Precautions
Separate plasma from cells and freeze immediately if not processed within 3 hours. Result affected by contraceptives and anticoagulants.
Normal Range
200 - 400 mg/dL 2.0 - 4.0 g/L
