Human Leukocyte Antigens (HLA) DR/DQ (Class II) Low/ Intermediate Genotyping


Human Leukocyte Antigens Class II molecules, which include DR, are the predominant presenters of exogenous antigens to T cells. These key molecules are critical for numerous aspects of immune function, including T-cell selection, tolerance induction, antibody production, T-cell-mediated immunity, and the inflammatory response. As principal mediators of transplant organ rejection, these molecules are often common targets for immune therapies to prevent the rejection of grafted tissues.


HLA-DR typing becomes important before organ transplantation. Typing is also used to identify markers for specific diseases. Class II HLA is implicated as a contributing factor in a host of diseases ranging from rheumatoid arthritis and diabetes to Alzheimer’s disease and multiple sclerosis.

Sample Type, Quantity & Conditions

2 ml EDTA Room Temperature

Special Precautions

Collect in EDTA vacutainer tube. Avoid contamination with DNA of phlebotomist. Avoid haemolysed samples. Do not freeze samples. Send tube unopened.

Normal Range

By Report

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