Lupus Anticoagulant (LAC), Plasma


The term lupus anticoagulant is a double misnomer, since most patients with lupus anticoagulant do not have lupus, and in vivo it is a procoagulant rather than an anticoagulant. Lupus anticoagulant inhibits phospholipid-dependent coagulation, so there may be prolongation of activated partial thrombin time (APTT). According to the Jordanian Scientific and Standardisation Committee guidelines, LAC may be considered if the following diagnostic criteria occur simultaneously (a) one (or more) phospholipid-dependent test is prolonged; (b) the above prolongation is not corrected when plasmas from the patient and a healthy control are mixed; and (c) the prolongation recorded for patient plasmas is corrected by increasing the concentration of phospholipids in the test system. See Also Anti phospholipid Antibodies , Cardiolipin Antibodies, IgG,Serum p.80, β-2-Glycoprotein 1 Antibodies, Serum and ANA


This test is useful in the diagnosis and follow up of thrombotic events. LAC is implicated in obstetric events, which include foetal death at or beyond the tenth week of gestation, premature birth at or before the thirty-fourth week, or spontaneous abortions before the tenth week.

Sample Type, Quantity & Conditions

3 ml Citrated Plasma Frozen

Special Precautions

Minimum 2 ml plasma required. Freeze immediately.

Normal Range

36.0 - 49.0 Seconds

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