Neutrophil Cytoplasmic Antibodies (ANCA), Serum



Anti-neutrophil cytoplasmic autoantibodies (ANCA) are a serological marker useful in the diagnosis of vasculitis, glomerulonephritis and Wegener’s granulomatosis. ANCA exhibits two patterns c-ANCA and p-ANCA. c-ANCA (PR3-ANCA) has a high (>90%) positive predictive value for Wegener’s granulomatosis. p-ANCA (MPO-ANCA) shows high (>80%) association with pauciimmune glomerulonephritis. The combination of these two tests with the anti-GBM antibody test is very useful for patients with Pulmonary renal syndromes or rapidly progressive glomerulonephritis. See Also Myeloperoxidase (MPO) Antibodies, Serum and Proteinase 3 (PR3) Antibodies, Serum

Sample Type, Quantity & Conditions

1 ml Serum Stability: 14 Days at 2-8 °C

Special Precautions

Titre Cytoplasmic or perinuclear types are reported.

Normal Range


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