Protein C Antigen Assay (Functional), Plasma


Protein C, a vitamin K-dependent zymogen of a serine protease synthesised in the liver, is a key component of an important natural anticoagulant pathway. It exerts its anticoagulant effect by regulating the activities of FVIIIa and FVa. The activation of protein C is catalysed by thrombin bound to thrombomodulin on the endothelial cell surface and by binding to endothelial protein C receptor. Protein S and intact factor V further enhance the activity of Protein C. In addition to its anticoagulant activity, Protein C has been shown to have anti-inflammatory and anti-apoptotic properties. Activated protein C is inhibited by protein C inhibitor, α-1-antitrypsin, and α-2- macroglobulin. See Also Protein S Antigen Assay, Total and Free and Plasma Activated protein C resistance (Factor V leiden) and its mutation.


Protein C deficiency results in thrombophilia and thromboembolic disease. Several deficiencies of protein C, both inherited and acquired, have been identified; some are from decreased concentrations of protein C in plasma (type I), whereas others reflect abnormalities in the molecule itself (Type II). Acquired Protein C deficiency can result from certain pathologies such as disseminated intravascular coagulation, severe burns, and liver disease.

Sample Type, Quantity & Conditions

1 ml Citrate Plasma Frozen

Special Precautions

Separate and freeze immediately. Avoid serum, unfrozen and haemolysed samples.

Normal Range

Of Pooled Normal Plasma: 65 - 150 70-130%

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