Description
Bone turnover markers are products of the osteoblasts or osteoclasts. The osteoblasts synthesise many proteins, and several of these are unique to the osteoblasts. The pyridinium crosslinks are formed between and within collagen molecules from lysine and hydroxylysine residues once the collagen fibres line up in a quarter-stagger array. The crosslinks include Pyridinoline (PYD) and Deoxypyridinoline (DPD); these may be excreted in the urine in the free form, or attached to the terminal residues of the collagen molecule, the so called C- and N-terminal telopeptides (CTX and NTX).
Indications
Pyridinoline and deoxypyridinoline are biochemical bone markers that provide a valuable tool in the management of metabolic bone diseases. Their most recognised application in clinical practice is for monitoring treatment for osteoporosis as an adjunct to bone mineral density measurements.
Sample Type, Quantity & Conditions
10 ml of 24 Hrs Urine Room Temperature
Special Precautions
State 24 Hrs urine volume.
Normal Range
Pyridinoline: Female: < 50 yrs: 105 - 185 μg/g Creat > 50 yrs: 115 - 210 μg/g Creat Male: 95 - 215 μg/g Creat Desoxypyridinoline: Female: < 50 yrs: 20 - 40 μg/g Creat > 50 yrs: 20 - 65 μg/g Creat Male: 15 - 45 μg/g Creat
