Tobramycin, Serum

Tobramycin is an aminoglycoside antibiotic. Aminoglycosides are highly potent, broad-spectrum antibiotics with many desirable properties for the treatment of life-threatening infections. This class of antibiotics is useful for the treatment of gram-negative bacillary infections. Aminoglycosides act primarily by impairing bacterial protein synthesis through binding to prokaryotic ribosomes. Whereas all clinically used aminoglycosides are inhibitors of prokaryotic protein synthesis at commonly accepted therapeutic concentrations, they may also affect the protein synthesis of mammalian cells at larger concentrations. Tobramycin overdose can cause otovestibular toxicity and nephrotoxicity.

Measurement of Tobramycin levels is performed to ensure concentrations are within therapeutic range and avoid drug toxicity.

1 ml Serum Room Temperature

Therapeutic Range: Peak level: 5 - 10 μg/L Trough level: 0.5- 2 μg/L Toxic: Peak level: > 10 μg/L Trough level: > 2 μg/L