Troponin T, Whole Blood

The troponin complex, troponin I, T, and C, along with tropomyosin, is located on the actin filament of the muscle and is essential for the calcium-mediated regulation of skeletal and cardiac muscle contraction. Cardiac Troponin T and I have amino acid sequences that differ from adult skeletal forms, which make their quantification organ specific. The cytosolic pool or content for Troponin T is 2-3 times higher than that for Troponin I, however, they are both released into the circulation after cardiac muscle damage. Elevated levels persist in the blood owing to the slow release and degradation of their structural pool and the 2 hours half -life. Thus, allowing for increased clinical detection of cardiac events.

Troponin T is a sensitive marker of myocardial injury (myocardial infarction, unstable angina pectoris following artery bypass grafting, and myocarditis) during the first 6 hours after chest pain making it superior to CK-MB whose characteristic release requires 8-12 hours after the onset of myocardial infarction symptoms. Besides myocardial infarction, troponin T is indicated in patients with acute cardiac ischemia; elevated Troponin T suggests that patients have increased risk for frank infarction or cardiac death. Moreover, for patients with acute coronary syndromes, heart failure and pulmonary embolism, diagnostic elevations invariably have prognostic and therapeutic significance.

1 ml Heparinised Venous Whole Blood Stability: 8 Hours at Room Temperature

Do not refrigerate or freeze sample.

Low Risk: < 50 ng/L Moderate Risk: 50-100 ng/L High Risk: > 100 ng/L