Vitamin D, 25-Hydroxy, Serum/Plasma


Sunlight UV rays induce the conversion of 7-dehydro-cholesterol to Pre-vitamin D which is thermally isomerised to vitamin D in the skin. The formation of 25-OH- vitamin D, which takes place in the liver, is the first step in the bioactivation of vitamin D. The vitamin D endocrine system is an essential component of the interactions among the kidney, bone, parathyroid gland and intestine that maintain extracellular calcium levels within narrow limits, a process vital for normal cellular physiology and skeletal integrity. See Also Vitamin D, 1, 25- Dihydroxy, Serum


The levels of 25-OH- Vitamin D increase in proportion to vitamin D intake and synthesis and are commonly used as an indicator of vitamin D status. Low vitamin D levels are associated with many diseases including rickets, autoimmune disease, hypertension and cancer.

Sample Type, Quantity & Conditions

1 ml Serum 1 ml K2, K3-EDTA or Li-Heparin Plasma Stability: 8 Hours at 18-25 °C 4 Days at 2-8 °C 24 Weeks at -20 °C

Special Precautions

Normal Range

Deficiency: < 20 ng/mL < 50 nmol/L Insufficiency: 20 - 29 ng/mL 50 - 74 nmol/L Sufficiency: 30 - 100 ng/mL 75 - 250 nmol/L Toxicity: >100 ng/mL > 250 nmol/L

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