Description
Y-chromosome microdeletions constitute one of the most common specific causes of genetic aetiology of severe testiculopathy and male infertility with an overall prevalence in infertile men of 8.2%. These
deletions are not visible at the cytogenetic level and are detectable only by PCR or Southern hybridisation.
Indications
Knowledge of the YCM and its prevalence is fundamental both for a careful diagnosis of male infertility and for its treatment. Y-chromosome screening is now a reality in major andrological and infertility centres. The detection of a deletion in an infertile man provides accurate diagnosis of the disease, allows the clinician to avoid empirical, unnecessary, and often expensive treatments to improve fertility (e.g., hormonal treatments), and highlights important ethical consequences if the patient is a candidate for assisted reproduction.
Sample Type, Quantity & Conditions
3 ml EDTA Whole Blood Room Temperature
Special Precautions
Collect in EDTA vacutainer tube. Avoid contamination with DNA of phlebotomist and send tube unopened Avoid haemolysed samples. Do not freeze samples.
Normal Range
No Deletions Detected
