Recurrent Miscarriage

It is known that overall 15% of all recognized pregnancies end in miscarriage. Recurrent miscarriage is diagnosed when a woman miscarries 3 consecutive times, before 20 weeks gestation.

What factors make one prone to recurrent miscarriage?

  • Autoimmune diseases: diseases that affect placental function and disturb early implantation.
  • Chromosome problems: here, both parents are fine, but when their genes are put together, an unusual gene mismatch occurs that may result in miscarriage.
  • Genetic predispositions for thrombophilias.
  • Maternal infections that may be passed onto the fetus.
  • Polycystic ovarian syndrome (PCO)
  • Thyroid hormone imbalances.

What laboratory investigations can be done?

  • Autoimmune tests: ANA, Cardiolipin Antibodies, Lupus
  • Anti-coagulant and TPO.
  • Chromosomal testing: parental blood karyotyping  and (fetal miscarriage tissue where applicable).
  • Tests for thrombophilias: Factor V Leiden, Factor II, MTHFR.
  • Tests for infections: Rubella, CMV, Hepatitis B and C.
  • Hormone profile for PCO: free testosterone and LH.
  • Thyroid testing: TSH, T3, T4 and TPO.
  • Blood group test for Rh factor compatibility for parents.

MedLabs’ Suggested Recurrent Miscarriage Panel

  • Cardiolipin Antibodies
  • Phospholipid Antibodies
  • Sperm Antibodies
  • Anti-Thrombin III
  • Lupus Anti-Coagulant
  • Factor V Leiden (PCR)
  • Factor II
  • Protein S Free Antigen
  • Protein C Functional

Physician consultation is recommended

Open chat
Scan the code
Hello 👋
Can we help you?