Insulin-Like Growth Factor Binding Protein-3, Serum/Plasma

Insulin-like growth factor binding protein-3 (IGFBP-3) is one of a family of six IGFBPs, multifunctional proteins that transport and stabilise IGFs in the circulation, modulate the effects of IGF on a variety of cellular functions, and may also regulate cells by IGF independent mechanisms. IGFBP-3 is by far the most abundant IGFBP in the circulation, where it has a central role in regulating IGF bioavailability to the tissues. In addition, IGFBP-3 is proposed to act by inhibiting the access of IGF to the type I IGF receptor, which mediates most of the actions of IGF.

Biological functions of IGF-I and IGF-II are modulated by specific high-affinity IGFBP-3. Low levels of IGFBP-3 is associated with liver disease and cirrhosis and correlate with liver dysfunction. Elevated IGFBP-3 levels have been found in patients with active acromegaly.

1 ml Serum 1 ml Heparinized Plasma Stability: 24 Hours at 22 °C 24 Hours at 2-8 °C 12 Months at -25 °C

Avoid grossly haemolysed or grossly lipemic samples.

As per Report