Cortisol, Total, Serum/Plasma


Cortisol is a corticosteroid hormone produced by the adrenal cortex, which is stimulated by adrenocorticotropic hormone (ACTH) which is secreted from the pituitary gland. Cortisol is effective in anti-inflammatory activity and blood pressure maintenance. In addition, it is involved in gluconeogenesis, calcium absorption and the secretion of gastric acid and pepsin. Cortisol level follows diurnal variations, reaching the highest level in the early morning, and the lowest level in the evening.See Also ACTH


Hypercortisolism (elevated level of cortisol) is found in Cushing’s syndrome. Decreased levels of cortisol (Hypocortisolism) or adrenal insufficiency is associated with Addison’s disease. Abnormal levels of cortisol may exist in patients with acute infections, diabetes mellitus, or heart failure, and in pregnant women or women on oestrogen therapy.

Sample Type, Quantity & Conditions

1 ml Serum 1 ml K2, K3-EDTA or Li-Heparin Plasma Stability: 24 Hours at 20-25 °C 4 Days at 2-8 °C 12 Months at -20 °C

Special Precautions

State time taken, preferably early morning or late evening. Separate serum or plasma from cells as soon as possible. Freeze only once.

Normal Range

Morning (6-10 a.m.): 6.02-18.4 µg/dL 166-507 nmol/L Afternoon (4-8 p.m.): 2.68-10.5 µg/dL 73.8-291 nmol/L

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