Description
Delta aminolevulinic acid (DALA) is an intermediate in the biosynthesis of porphyrin and is a precursor in haem synthesis. haem synthesis abnormalities due to ALA dehydretase deficiency and Lead poisoning, lead to the accumulation of DALA, which results in abnormal pharmacological and neurological effects and symptoms. These include abdominal-neurological crises with cardiovascular symptoms, persistent paresis and transient respiratory paralysis.
Indications
This test is useful in the diagnosis of ALA Dehydreatase Deficiency Porphyria, and intermittent severe acute hepatic porphyria syndrome, and is used as a marker of lead poisoning.
Sample Type, Quantity & Conditions
30 ml of 24 Hrs Urine Room Temperature
Special Precautions
Instruct the patient to void at 8 a.m. and discard the specimen. Then collect all urine including the final specimen voided at the end of the 24-hour collection period (i.e., 8 a.m. the next morning). Measure and record total 24-hour urine volume.
Normal Range
By Report
