Human Oncogenes, Breast Cancer (BRCA1 and BRCA2), Gene Analysis

The BRCA1 and BRCA2 proteins are involved in the regulation of gene transcription and DNA. BRCA1 is a tumour-suppressor gene postulated to be important in regulating the growth of breast epithelial cells. Mutations in BRCA1 and BRCA2, seem to be responsible for the majority of breast cancers associated with hereditary breast and ovarian cancer (HBOC). Ovarian cancer is _reported to be more common in BRCA1 mutation carriers than in BRCA2 mutation carriers. Individuals with BRCA1 and BRCA2 mutations have a lifetime risk of 90% to developing cancer.

Breast cancer attributed to a family history of the disease has been reported to account for 6 to 19 percent of all cases of breast cancer. BRCA1 mutations accounts for 45 percent of hereditary cases of breast cancer and 80 to 90 percent of hereditary cases of combined breast and ovarian cancers.

3 ml EDTA Whloe Blood Room Temperature

Collect in EDTA vacutainer tube. Avoid contamination with DNA of phlebotomist. Avoid haemolysed samples. Do not freeze samples. Send tube unopened.

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