Red Blood Cell Inclusion Bodies

Normally a red blood cell (RBC) does not contain inclusions in the cytoplasm. However, inclusion bodies may be seen due to certain hematologic disorders. There are three kinds of red cell inclusions: 1. Developmental Organelles (Howell-Jolly Bodies: small, round fragments of the nucleus resulting from karyorrhexis or nuclear disintegration of the late reticulocyte, Basophilic Stipplings,Pappenheimer Bodies orsiderotic granules which are small, irregular, dark-staining granules that appear near the periphery of a young RBC and Cabot Rings: ring-like structure that may appear in RBCs in megaloblastic anaemia or in severe anemias, lead poisoning, and in dyserythropoiesis). 2. Abnormal Hemoglobin Precipitation (Heinz Bodies: round, refractile inclusions and Haemoglobin H Inclusions seen in α-Thalassemia). 3.Protozoan Inclusion (Malaria and Babesia).

Different forms or types of RBC inclusion bodies are associated with certain hematological abnormalities.

1 ml EDTA Whole Blood Room Temperature

Negative