×

Renin Activity, Plasma

Description

Activation and secretion of renin initiate an enzymatic cascade which results in the generation of angiotensin I and the subsequent generation of angiotensin II, a hormone that ultimately integrates cardiovascular and renal function in the control of blood pressure as well as salt and volume homeostasis. In addition, renin is involved in cell growth and apoptosis. Renin is synthesised in the juxtaglomerular cells of the kidney, salivary glands, cells of the adrenal cortex, neurones and other tissues. However, the majority of circulating renin is derived from the kidney.

Indications

Primary hyper-aldosteronism is classically characterised by a combination of hypertension, hypo-kalaemia, suppressed renin and an elevated non-suppressible aldosterone concentration. Aldosterone concentration to plasma renin activity ratio is used as a screening tool for the diagnosis of primary hyper-aldosteronism since it is independent of diurnal and day-to-day variations of salt intake and diuretics. Decreased Renin levels are also seen in patients with Cushing’s disease, liver cirrhosis and severe cardiac failure. Elevated levels are seen in secondary hyper-aldosteronism and Addison’s disease. See Also Angiotensin converting Enzyme and Aldosterone levels

Sample Type, Quantity & Conditions

1 ml EDTA Plasma

Special Precautions

Patient should be fasting. Collect sample between 8 - 10 am. Draw blood into ice-cooled tube and send to lab under ice.

Normal Range

Supine: 4.7 - 31.9 pg/mL Erect : 7.5 - 42.0 pg/mL

Open chat
1
Scan the code
Hello 👋
Can we help you?